January 1991
Volume 32, Issue 1
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Articles  |   January 1991
Immunoglobulin G receptor-mediated phagocytosis by the pigmented epithelium of the ciliary processes.
Author Affiliations
  • N S Peress
    Research & Development Service, Department of Veterans Affairs Medical Center, Northport, New York.
  • E Perillo
    Research & Development Service, Department of Veterans Affairs Medical Center, Northport, New York.
Investigative Ophthalmology & Visual Science January 1991, Vol.32, 78-87. doi:
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      N S Peress, E Perillo; Immunoglobulin G receptor-mediated phagocytosis by the pigmented epithelium of the ciliary processes.. Invest. Ophthalmol. Vis. Sci. 1991;32(1):78-87.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The current ultrastructural study of cultured explants of bovine and rabbit posterior ciliary processes using immunoglobulin (Ig) G-opsonized red blood cells (E-IgG) showed specific IgG Fc receptor-mediated attachment, ingestion, and digestion of IgG-coated erythrocytes by the pigmented epithelium (PE). Nonpigmented epithelial cells (NPE) in the cultured explants and a transformed cell line of bovine NPE, with and without lymphokine stimulation, did not have IgG-receptor activity. The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris. Disintegration of some surface-associated E-IgG was also observed and was consistent with the release of a lytic substance by the receptor-activated PE.

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