May 1991
Volume 32, Issue 6
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Articles  |   May 1991
Autoradiographic mapping of the glucose transporter with cytochalasin B in the mammalian eye.
Author Affiliations
  • P Kaulen
    Department of Ophthalmology, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Berlin, FRG.
  • G Kahle
    Department of Ophthalmology, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Berlin, FRG.
  • K Keller
    Department of Ophthalmology, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Berlin, FRG.
  • J Wollensak
    Department of Ophthalmology, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Berlin, FRG.
Investigative Ophthalmology & Visual Science May 1991, Vol.32, 1903-1911. doi:
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    • Get Citation

      P Kaulen, G Kahle, K Keller, J Wollensak; Autoradiographic mapping of the glucose transporter with cytochalasin B in the mammalian eye.. Invest. Ophthalmol. Vis. Sci. 1991;32(6):1903-1911.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The anatomic localization of the glucose transport protein in the eyes of rats, rabbits, baboons, marmosets, and humans with [3H]cytochalasin B using in vitro autoradiography showed high densities of glucose carrier densities. These densities were seen in the ciliary body, especially ciliary processes, iris, retina, and in some species, the trabecular meshwork and lens. In the lens, specific [3H]cytochalasin B-binding sites were mainly concentrated in the lens nucleus. Lower concentrations were found in the cortex. During aging, glucose transporter concentration increases up to the age of 8 yr in the marmoset lens nucleus, but decreases in the cortex and retina. Moderate amounts of carrier are located in the corneal endothelium and epithelium. The enrichment of glucose carrier protein in the trabecular meshwork suggests a high metabolic activity and a possible relationship in the regulation of intraocular pressure.

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