May 1991
Volume 32, Issue 6
Free
Articles  |   May 1991
Microspheres of biodegradable polymers as a drug-delivery system in the vitreous.
Author Affiliations
  • T Moritera
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • Y Ogura
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • Y Honda
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • R Wada
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • S H Hyon
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • Y Ikada
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Investigative Ophthalmology & Visual Science May 1991, Vol.32, 1785-1790. doi:
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    • Get Citation

      T Moritera, Y Ogura, Y Honda, R Wada, S H Hyon, Y Ikada; Microspheres of biodegradable polymers as a drug-delivery system in the vitreous.. Invest. Ophthalmol. Vis. Sci. 1991;32(6):1785-1790.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Microspheres of biodegradable polymers were evaluated as a potential controlled-release drug-delivery system in the vitreous. The microspheres were prepared with polymers of poly(lactic acid) or copolymers of glycolic acid and lactic acid. The release of 5-fluorouracil (5-FU) from the microspheres was studied in vitro. Poly(lactic acid) microspheres released 70-85% of total 5-FU over 7 days. Microspheres of polymers with a smaller molecular weight released the drug more rapidly. Copolymer microspheres released 98% of 5-FU over 2 days. The rate of drug release was controllable by changing the molecular weight of the polymers or using a matrix of copolymer. The intravitreal kinetics of the microspheres were studied in ten rabbits in vivo. A suspension of microspheres was injected into the vitreous cavity of five normal eyes and five vitrectomized eyes. By 48 +/- 5.2 days after injection, the microspheres disappeared from the vitreous cavity in the five normal eyes. Clearance from the vitreous cavity was accelerated in the five rabbits that underwent vitrectomy (14 +/- 2.4 days; P less than 0.001). No difference was found in the b waves of electroretinograms before and after injection of the microspheres. The histologic study showed no abnormal findings as a result of the injection. These results suggested that microspheres of biodegradable polymers may be a potential delivery system for the controlled release of drugs in the vitreous.

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