September 1991
Volume 32, Issue 10
Free
Articles  |   September 1991
Basic fibroblast growth factor (FGFb) and epidermal growth factor (EGF) receptor messenger RNA production in human lacrimal gland.
Author Affiliations
  • S E Wilson
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas.
  • S A Lloyd
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas.
  • R H Kennedy
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas.
Investigative Ophthalmology & Visual Science September 1991, Vol.32, 2816-2820. doi:
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    • Get Citation

      S E Wilson, S A Lloyd, R H Kennedy; Basic fibroblast growth factor (FGFb) and epidermal growth factor (EGF) receptor messenger RNA production in human lacrimal gland.. Invest. Ophthalmol. Vis. Sci. 1991;32(10):2816-2820.

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Abstract

The polymerase chain reaction (PCR) was used to show that basic fibroblast growth factor (FGFb) and epidermal growth factor (EGF) receptor messenger ribonucleic acids (RNA) are produced in human lacrimal tissue. Transforming growth factor beta-1 (TGF beta-1) messenger RNA was not detected. These results and the previous identification of EGF in the lacrimal gland suggest that EGF could have autocrine or paracrine functions in lacrimal tissue. FGFb could also serve autocrine or paracrine functions in lacrimal gland physiology. It is also plausible that FGFb is released by the lacrimal gland into the tears and that the growth factor may have regulatory effects on the cells of the ocular surface.

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