January 1991
Volume 32, Issue 1
Free
Articles  |   January 1991
Immune privilege extended to allogeneic tumor cells in the vitreous cavity.
Author Affiliations
  • L Q Jiang
    Department of Microbiology and Immunology, School of Medicine, University of Miami, FL 33101.
  • J W Streilein
    Department of Microbiology and Immunology, School of Medicine, University of Miami, FL 33101.
Investigative Ophthalmology & Visual Science January 1991, Vol.32, 224-228. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      L Q Jiang, J W Streilein; Immune privilege extended to allogeneic tumor cells in the vitreous cavity.. Invest. Ophthalmol. Vis. Sci. 1991;32(1):224-228.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Inoculation of alloantigenic P815 tumor cells into the vitreous cavity of eyes of BALB/c mice resulted in the intraocular development of progressively growing tumors. We observed by clinical and histologic examination that the tumors acquired a blood supply, lacked significant necrosis or degeneration, and gradually penetrated the globe into the orbit. Mice bearing these intraocular tumors did not develop tumor-specific delayed hypersensitivity (DH), and their spleens contained lymphocytes capable of suppressing tumor-specific DH when transferred adoptively into naive, syngeneic recipients. The authors conclude that the vitreous cavity (VC) is an immunologically privileged site for histoincompatible tumor cells and that the privilege is mediated by active suppression of DH, similar to anterior chamber (AC)-associated, immune deviation.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×