January 1991
Volume 32, Issue 1
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Articles  |   January 1991
Endothelin-1-induced contraction of bovine retinal small arteries is reversible and abolished by nitrendipine.
Author Affiliations
  • N C Nyborg
    Department of Pharmacology, Aarhus University, Denmark.
  • D Prieto
    Department of Pharmacology, Aarhus University, Denmark.
  • S Benedito
    Department of Pharmacology, Aarhus University, Denmark.
  • P J Nielsen
    Department of Pharmacology, Aarhus University, Denmark.
Investigative Ophthalmology & Visual Science January 1991, Vol.32, 27-31. doi:
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      N C Nyborg, D Prieto, S Benedito, P J Nielsen; Endothelin-1-induced contraction of bovine retinal small arteries is reversible and abolished by nitrendipine.. Invest. Ophthalmol. Vis. Sci. 1991;32(1):27-31.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Endothelin-1 (porcine/human) induced a prompt, reversible, potent, concentration-dependent contraction of bovine isolated retinal small arteries (internal diameter, approximately 200 microns) with a concentration of endothelin-1 required to give half-maximal contraction of 2 x 10(-10) M. The maximal contraction induced by endothelin-1 was equal to 89% of the maximal contractile capacity. The vessel response to endothelin-1 was dependent on extracellular Ca2+. Withdrawal of extracellular Ca2+ or addition of nitrendipine, 10(-6) M, reduced the response of vessels contracted with 10(-9) M endothelin-1 by 80% and 75%, respectively. These results indicate that the endothelin-1-induced contraction of retinal arteries is dependent on an influx of extracellular Ca2+ through membrane potential-operated calcium channels. Endothelin-1, 10(-13)-10(-10) M, did not induce a relaxation of endothelium-intact arteries, indicating that endothelin-1 is incapable of releasing endothelium-derived relaxing factor in the retinal circulation. These results suggest that endothelin may participate in the regulation of retinal artery tone.

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