May 1991
Volume 32, Issue 6
Free
Articles  |   May 1991
Halogenated inhalation anesthetic agents decrease transepithelial electrical measurements across the isolated iris-ciliary body.
Author Affiliations
  • L Q Tang
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
  • T Krupin
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
  • M Milner
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
  • D Woods
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
  • K Miller
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
  • D A Carré
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
  • M M Civan
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
Investigative Ophthalmology & Visual Science May 1991, Vol.32, 1912-1915. doi:
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    • Get Citation

      L Q Tang, T Krupin, M Milner, D Woods, K Miller, D A Carré, M M Civan; Halogenated inhalation anesthetic agents decrease transepithelial electrical measurements across the isolated iris-ciliary body.. Invest. Ophthalmol. Vis. Sci. 1991;32(6):1912-1915.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-dependent decrease in the short-circuit current (SCC) and potential difference (PD). This response was reversible after the anesthetic gas was discontinued. Pretreatment with either alpha-adrenergic or beta-adrenergic antagonists (phentolamine or timolol) had no effect on the halothane-induced decrease in SCC. Delivery of the analgestic gas N2O did not alter baseline electrical measurements across the isolated I-CB.

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