June 1991
Volume 32, Issue 7
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Articles  |   June 1991
Effect of fibronectin on corneal epithelial wound healing in the vitamin A-deficient rat.
Author Affiliations
  • K Watanabe
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
  • G Frangieh
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
  • C V Reddy
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
  • K R Kenyon
    Cornea Unit, Eye Research Institute, Boston, MA 02114.
Investigative Ophthalmology & Visual Science June 1991, Vol.32, 2159-2162. doi:
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    • Get Citation

      K Watanabe, G Frangieh, C V Reddy, K R Kenyon; Effect of fibronectin on corneal epithelial wound healing in the vitamin A-deficient rat.. Invest. Ophthalmol. Vis. Sci. 1991;32(7):2159-2162.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The authors investigated the in vitro and in vivo effects of fibronectin (Fn) on the migration of corneal epithelium of vitamin A-deficient (A-) and pair-fed control (A+) rats. Groups treated with 50 micrograms/ml Fn showed accelerated healing of epithelium in vitro (P less than 0.05) compared with control groups of A- and A+ rats. However, when 100 micrograms/ml Fn eye drops were administered 14 times over 20 hr, they had no significant effect on A+ rats in vivo, but increased the healing in A- rats (P less than 0.05). In this model, Fn promoted the healing of corneal epithelium under A- conditions where decreased endogenous Fn is seen, whereas A+ corneas in vivo, which have sufficient Fn over the wound surface, did not benefit from topical Fn administration.

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