May 1994
Volume 35, Issue 6
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Articles  |   May 1994
Topical application of a cyclic GMP analog lowers IOP in normal and ocular hypertensive rabbits.
Author Affiliations
  • P J Stein
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut.
  • J W Clack
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut.
Investigative Ophthalmology & Visual Science May 1994, Vol.35, 2765-2768. doi:
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      P J Stein, J W Clack; Topical application of a cyclic GMP analog lowers IOP in normal and ocular hypertensive rabbits.. Invest. Ophthalmol. Vis. Sci. 1994;35(6):2765-2768.

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Abstract

PURPOSE: To determine whether a new cyclic GMP analog, 2'-O-(4-benzoyl)benzoylguanosine 3',5' cyclic monophosphate (BB-cGMP), significantly reduces intraocular pressure in either normotensive or hypertensive eyes of rabbits. METHODS: Intraocular pressure of normal adult rabbits and/or rabbits with alpha-chymotrypsin-induced ocular hypertension was measured after topical application of BB-cGMP for up to 72 hours after treatment. RESULTS: Data indicate that topical application of solutions containing BB-cGMP can significantly reduce intraocular pressure in normotensive eyes and, to a greater extent, hypertensive eyes for periods up to 12 hours for a single dose. CONCLUSIONS: BB-cGMP holds interest both as a clinical agent in the management of intraocular pressure and for in vitro biochemical studies on the regulation of intraocular pressure.

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