June 1994
Volume 35, Issue 7
Free
Articles  |   June 1994
Retinal circulatory abnormalities in type 1 diabetes.
Author Affiliations
  • G T Feke
    Schepens Eye Research Institute, Boston, MA 02114.
  • S M Buzney
    Schepens Eye Research Institute, Boston, MA 02114.
  • H Ogasawara
    Schepens Eye Research Institute, Boston, MA 02114.
  • N Fujio
    Schepens Eye Research Institute, Boston, MA 02114.
  • D G Goger
    Schepens Eye Research Institute, Boston, MA 02114.
  • N P Spack
    Schepens Eye Research Institute, Boston, MA 02114.
  • K H Gabbay
    Schepens Eye Research Institute, Boston, MA 02114.
Investigative Ophthalmology & Visual Science June 1994, Vol.35, 2968-2975. doi:
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      G T Feke, S M Buzney, H Ogasawara, N Fujio, D G Goger, N P Spack, K H Gabbay; Retinal circulatory abnormalities in type 1 diabetes.. Invest. Ophthalmol. Vis. Sci. 1994;35(7):2968-2975.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To quantify retinal circulatory abnormalities in patients with type 1 diabetes; to 1 diabetes; to compare blood speed and blood flow in major temporal retinal arteries as well as total retinal arterial cross-section measured in patients to that measured in controls without diabetes; to determine which factors are related to the measured abnormalities within the patient group. METHODS: The laser Doppler technique and monochromatic fundus photography were used to measure retinal circulatory parameters in 39 patients with type 1 diabetes with duration of diabetes between 7 and 20 years and 13 age-matched controls without diabetes. Blood pressure, intraocular pressure, and heart rate were measured in all subjects. Glycosylated hemoglobin was measured in the patients. Retinopathy was assessed using standardized color fundus photography and fluorescein angiography. RESULTS: Total retinal arterial cross-section was, on average, 17% higher (P = 0.007) in the patients than in the controls, and it increased with increasing duration of diabetes (P = 0.006). Arterial blood speed was, on average, 33% lower (P = 0.0001) in the patients than in the controls, and it decreased with increasing duration of diabetes (P = 0.03). CONCLUSIONS: The retinal circulation of patients with type 1 diabetes with no retinopathy or background retinopathy is characterized by dilated major arteries with reduced blood speeds. Dilation of the larger retinal arteries, with the accompanying decrease in vascular resistance to flow in those vessels, appears to counteract an increase in resistance to flow at the level of the smaller retinal vessels.

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