August 1997
Volume 38, Issue 9
Free
Articles  |   August 1997
Endothelial metaplasia in the iridocorneal endothelial syndrome.
Author Affiliations
  • D N Howell
    Department of Pathology, Veterans Affairs Medical Center, Durham, North Carolina, USA.
  • T Damms
    Department of Pathology, Veterans Affairs Medical Center, Durham, North Carolina, USA.
  • J L Burchette, Jr
    Department of Pathology, Veterans Affairs Medical Center, Durham, North Carolina, USA.
  • W R Green
    Department of Pathology, Veterans Affairs Medical Center, Durham, North Carolina, USA.
Investigative Ophthalmology & Visual Science August 1997, Vol.38, 1896-1901. doi:
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    • Get Citation

      D N Howell, T Damms, J L Burchette, W R Green; Endothelial metaplasia in the iridocorneal endothelial syndrome.. Invest. Ophthalmol. Vis. Sci. 1997;38(9):1896-1901.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To test the hypothesis that the aberrant, cytokeratin-expressing cells that replace endothelium in the iridocorneal endothelial (ICE) syndrome are of endothelial origin. METHODS: Corneas from four patients with Chandler's syndrome and three with essential iris atrophy were examined by two-color immunofluorescence for simultaneous expression of cytokeratins and two markers of endothelial lineage: vimentin and the antigen recognized by the antiendothelial monoclonal antibody 2B4.14.1. RESULTS: In six corneas, unequivocal endothelial staining for cytokeratins was present; in each of these, cells coexpressing cytokeratins and the two endothelial markers were clearly identifiable. In the remaining cornea, weak cytokeratin staining that colocalized with vimentin was present. CONCLUSIONS: These results lend strong support to the hypothesis that the "epithelial-like" endothelial cells in ICE syndrome are cells of endothelial lineage rather than heterotopia of epithelial cells; these cells probably arise via a metaplastic transformation of preexisting endothelium.

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