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Stuart K. Gardiner, Chris A. Johnson, George A. Cioffi; Evaluation of the Structure-Function Relationship in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2005;46(10):3712-3717. doi: 10.1167/iovs.05-0266.
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purpose. While glaucoma is evaluated on the basis of structural and functional test results, the spatial relationship between structure and function is not well defined. This study produces a topographical map to demonstrate how sectors of the optic nerve head (ONH) are related to locations in the visual field, using empiric cross-sectional patient data.
methods. One hundred nine subjects with healthy eyes and 166 subjects with diagnosed or suspected glaucoma (one test per patient) were evaluated using a retina tomograph and white-on-white standard automated perimetry (SAP). The tomograph ONH images were divided into 36 sectors; and the sector rim areas normalized to account for changes in the total rim area. These were then correlated with SAP thresholds. For each visual field location, a map was produced indicating the strength of correlation between the normalized sector rim areas and thresholds.
results. The highest correlation between a sector’s normalized rim area and a SAP location’s sensitivity was 0.520. Twenty-seven of the 52 non–blind spot SAP locations exhibited a correlation greater than 0.2 with at least one ONH sector. Locations in the superior hemifield were usually best correlated with the polar inferior temporal sectors of the ONH; locations in the inferior hemifield were usually best correlated with the polar superior temporal sectors of the ONH.
conclusions. A map relating regions of the ONH to SAP test locations has been produced. This map may be useful in elucidating the structure-function relationship, particularly for cases of localized glaucomatous loss.
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