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Yasushi Ikuno, Kana Kawaguchi, Takeyoshi Nouchi, Yoshiaki Yasuno; Choroidal Thickness in Healthy Japanese Subjects. Invest. Ophthalmol. Vis. Sci. 2010;51(4):2173-2176. doi: 10.1167/iovs.09-4383.
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To study posterior choroidal thickness and its profile based on location in healthy Japanese subjects and the correlation with axial length, refractive error (RE), and age.
Eighty-six eyes of 43 healthy volunteers with no ophthalmic or systemic symptoms were examined with prototype high-penetration optical coherence tomography using a 1060-nm light source. Eyes with high myopia (exceeding −6 D) or with retinal/choroidal disease were excluded. The spherical equivalent RE was measured by autorefractometry, and the axial length was measured by partial coherence inferometry.
Mean choroidal thicknesses were 354 ± 111 μm at the fovea, 364 ± 86 μm superiorly, 345 ± 108 μm inferiorly, 227 ± 532 μm nasally, and 337 ± 102 μm temporally. Subfoveal choroidal thickness was significantly greater than nasal (P < 0.01) and temporal (P < 0.05) choroidal thickness; however, there was no significant difference compared with superior (P = 0.20) and inferior (P = 0.17) choroidal thickness. The temporal choroid was significantly (P < 0.01) thicker than the nasal choroid, and the inferior choroid was significantly (P < 0.01) thinner than the superior choroid. There was a significant negative correlation between foveal choroidal thickness and axial length (P < 0.05) but a borderline correlation with the RE (P = 0.086) and age (P = 0.07). Age was the factor that was most associated with the choroidal thickness (F = 20.86; P < 0.001), followed by RE (F = 5.37; P < 0.05); axial length was not a significant factor (F = 1.47; P = 0.22) by stepwise analysis.
The profile of choroidal thickness depends on its location. RE, axial length, and especially age are critical for evaluation of choroidal thickness.
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