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Thomas J. Harrison, Cyrus O. Abbasi, Tariq A. Khraishi; Purtscher Retinopathy: An Alternative Etiology Supported by Computer Fluid Dynamic Simulations. Invest. Ophthalmol. Vis. Sci. 2011;52(11):8102-8107. doi: 10.1167/iovs.11-7734.
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To explore an alternative etiology for Purtscher retinopathy by literature review and fluid dynamic computational simulations of wall shear stress (WSS) profiles.
Computer simulations were developed, incorporating posterior pole retinal microvascular flow parameters, to demonstrate WSS profiles at 90° and 45° angle artery/arteriolar branching.
Computer simulations reveal WSS profiles dependent on artery/arteriolar branching angles. At high flow rates an area of changed WSS and flow swirling and reversal was noted at the proximal fillet of the 90° arteriolar branching. These changes did not appear at the 45° arteriolar branching until the flow rate was increased an additional 30%.
Computer simulation data, as well as review of the history and clinical findings of Purtscher and Purtscher-like retinopathy, present evidence that an additional etiology for Purtscher retinopathy may be a rheological event at a retinal posterior pole foci of vascular endothelial dysregulation, followed by downstream endothelin-induced vasculopathy.
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