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Irene Sánchez, Vladimir Laukhin, Ana Moya, Raul Martin, Fernando Ussa, Elena Laukhina, Anton Guimera, Rosa Villa, Concepcio Rovira, Jordi Aguiló, Jaume Veciana, Jose C. Pastor; Prototype of a Nanostructured Sensing Contact Lens for Noninvasive Intraocular Pressure Monitoring. Invest. Ophthalmol. Vis. Sci. 2011;52(11):8310-8315. doi: https://doi.org/10.1167/iovs.10-7064.
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© ARVO (1962-2015); The Authors (2016-present)
To present the application of a new sensor based on a flexible, highly piezoresistive, nanocomposite, all-organic bilayer (BL) adapted to a contact lens (CL) for non-invasive monitoring intraocular pressure (IOP).
A prototype of a sensing CL, adapted to a pig eyeball, was tested on different enucleated pig eyes. A rigid, gas-permeable CL was designed as a doughnut shape with a 3-mm hole, where the BL film–based sensor was incorporated. The sensor was a polycarbonate film coated with a polycrystalline layer of the highly piezoresistive molecular conductor β-(ET)2I3, which can detect deformations caused by pressure changes of 1 mm Hg. The pig eyeballs were subjected to controlled-pressure variations (low-pressure transducer) to register the electrical resistance response of the CL sensor to pressure changes. Similarly, a CL sensor was designed according to the anatomic characteristics of the eye of a volunteer on the research team.
A good correlation (r 2 = 0.99) was demonstrated between the sensing CL electrical response, and IOP (mm Hg) changes in pig eyes, with a sensitivity of 0.4 Ω/mm Hg. A human eye test also showed the high potential of this new sensor (IOP variations caused by eye massage, blinking, and eye movements were registered).
A new nanostructured sensing CL for continuous monitoring of IOP was validated in an in vitro model (porcine eyeball) and in a human eye. This prototype has adequate sensitivity to continuously monitor IOP. This device will be useful for glaucoma diagnosis and treatment.
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