September 1990
Volume 31, Issue 9
Free
Articles  |   September 1990
Electrophysiological and psychophysical flicker sensitivity in patients with primary open-angle glaucoma and ocular hypertension.
Author Affiliations
  • K Holopigian
    Department of Ophthalmology, New York University Medical Center, New York 10016.
  • W Seiple
    Department of Ophthalmology, New York University Medical Center, New York 10016.
  • C Mayron
    Department of Ophthalmology, New York University Medical Center, New York 10016.
  • R Koty
    Department of Ophthalmology, New York University Medical Center, New York 10016.
  • M Lorenzo
    Department of Ophthalmology, New York University Medical Center, New York 10016.
Investigative Ophthalmology & Visual Science September 1990, Vol.31, 1863-1868. doi:
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    • Get Citation

      K Holopigian, W Seiple, C Mayron, R Koty, M Lorenzo; Electrophysiological and psychophysical flicker sensitivity in patients with primary open-angle glaucoma and ocular hypertension.. Invest. Ophthalmol. Vis. Sci. 1990;31(9):1863-1868.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Temporal sensitivity was assessed in patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). Three measures of flicker sensitivity were obtained: psychophysical modulation thresholds, visual-evoked potentials (VEPs), and focal electroretinograms (FERGs). We found elevated psychophysical thresholds at higher temporal frequencies (30-50 Hz) in patients with POAG, relative to thresholds for age-matched controls. The OHT patients had elevated psychophysical thresholds only at 50 Hz. On the other hand, VEP amplitudes in POAG patients were reduced at all temporal frequencies, with the magnitude of the loss increasing with temporal frequency. The OHT patients, however, showed no reductions in VEP amplitude at any temporal frequency. Finally, POAG patients' FERG amplitudes were reduced at 30-50 Hz; whereas FERG amplitudes in the OHT patients were normal at all temporal frequencies. These results indicate that OHT patients can exhibit psychophysical threshold losses at high temporal frequencies which are not observed in the suprathreshold electrophysiological amplitude measures. On the other hand, patients with POAG show both psychophysical and VEP losses across a range of temporal frequencies. In addition, the decreases in FERG amplitudes in POAG patients suggest changes in the functioning of the outer retina in this disease.

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