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Minna Huhtinen, Mirja Puolakkainen, Kirsi Laasila, Matti Sarvas, Anni Karma, Marjatta Leirisalo-Repo; Chlamydial Antibodies in Patients with Previous Acute Anterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2001;42(8):1816-1819.
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purpose. To determine the prevalence of antibodies to Chlamydia
pneumoniae, C. trachomatis, and C.
pneumoniae heat shock protein (Cpn Hsp60) in patients with
acute anterior uveitis (AAU) and in sex- and age-matched healthy
methods. Altogether 64 patients with previous AAU were examined at the Helsinki
University Eye Hospital from September through December 1999. Serum
specimens from the patients and sex- and age-matched healthy control
subjects were tested for antibodies to C. pneumoniae and C. trachomatis by a specific microimmunofluorescence
test and for antibodies to Cpn Hsp60 by enzyme immunoassay (EIA).
results. The prevalence of antibodies to C. pneumoniae (69% vs.
72%) and C. trachomatis (11% vs. 6%) did not differ
significantly between the patients and control subjects, nor did the
level of IgG antibodies to Cpn Hsp60 (median EIA unit, 65 vs. 48). The
levels of IgA antibodies to Cpn Hsp60 were significantly higher in the
patients with AAU than in the control subjects (median EIA unit, 18 vs.
10; two-tailed Wilcoxon signed rank test, P =
conclusions. The high frequency of IgA antibodies to Cpn Hsp60 in patients with past
AAU indicates that such patients may have persisting or recurrent
infections due to C. pneumoniae. This finding suggests
that C. pneumoniae may play a role in the pathogenesis
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