January 1970
Volume 9, Issue 1
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Articles  |   January 1970
Experimental Ocular Hypersensitivity to Polyepinephrine and its analogues
Author Affiliations
  • SAMUEL B. ARONSON
    Eye Research Laboratories, Department of Ophthalmology, and the Clinical Laboratories at San Francisco General Hospital, University of California School of Medicine, San Francisco, Calif.; Research Career Development Award USPHS K3-NB-31, 653.
  • RICHARD SASSETTI
    Eye Research Laboratories, Department of Ophthalmology, and the Clinical Laboratories at San Francisco General Hospital, University of California School of Medicine, San Francisco, Calif.
Investigative Ophthalmology & Visual Science January 1970, Vol.9, 12-19. doi:
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      SAMUEL B. ARONSON, RICHARD SASSETTI; Experimental Ocular Hypersensitivity to Polyepinephrine and its analogues. Invest. Ophthalmol. Vis. Sci. 1970;9(1):12-19.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Experimental hypersensitivity to epinephrine and to some of its analogues was induced in the rabbit. These changes included chemosis, limbal hyperemia, subepithelial corneal infiltrates, and anterior chamber cells and fare; changes already described in human epinephrine hypersensitivity. Positive skin reactions and circulating antibody were recorded after systemic immunization to polyepinephrine; only skin sensitivity occurred in polyaldomet immunization. This experimental model closely simulates epinephrine hypersensitivity as seen in man.

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