July 1970
Volume 9, Issue 7
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Articles  |   July 1970
Optic Nerve Transection and Intraocular Pressure Response to Various Drugs
Author Affiliations
  • STEVEN M. PODOS
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.
  • THEODORE KRUPIN
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.
  • BERNARD BECKER
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.
Investigative Ophthalmology & Visual Science July 1970, Vol.9, 492-495. doi:
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      STEVEN M. PODOS, THEODORE KRUPIN, BERNARD BECKER; Optic Nerve Transection and Intraocular Pressure Response to Various Drugs. Invest. Ophthalmol. Vis. Sci. 1970;9(7):492-495.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Base-line intraocular pressure was similar in the rabbit eye with a transected optic nerve and the opposite eye subjected to a sham operation. Hyperosmotic oral ethanol, at doses of 1.5 to 2.0 ml. per kilogram, lowered intraocular pressure significantly less in eyes with transected optic nerves than in their fellow eyes with intact optic nerves. Smaller doses of ethanol (0.75 ml. per kilogram) decreased intraocular pressure only in sham-operated eyes. Topically applied pilocarpine or epinephrine hydrochloride produced no difference between the intraocular pressures of the two eyes. Intravenous acetazolamide lowered intraocular pressure symmetrically in eyes with both intact and transected optic nerves.

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