November 1970
Volume 9, Issue 11
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Articles  |   November 1970
Protection by Polyinosinic-Polycytidylic Acid Complex of Rabbit Eye Tissue Cultures Infected with Herpes Simplex Virus
Author Affiliations
  • MERCEDES WEISSENBACHER
    Department of Ophthalmology of the New York Medical College, New York, N. Y., United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
  • MILES A. GALIN
    Department of Ophthalmology of the New York Medical College, New York, N. Y., United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
  • ENDLIAM CHOWCHUVECH
    Department of Ophthalmology of the New York Medical College, New York, N. Y., United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
  • NORBERT SCHACHTER
    Department of Ophthalmology of the New York Medical College, New York, N. Y., United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
  • SAMUEL BARON
    Department of Ophthalmology of the New York Medical College, New York, N. Y., United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
Investigative Ophthalmology & Visual Science November 1970, Vol.9, 857-864. doi:
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      MERCEDES WEISSENBACHER, MILES A. GALIN, ENDLIAM CHOWCHUVECH, NORBERT SCHACHTER, SAMUEL BARON; Protection by Polyinosinic-Polycytidylic Acid Complex of Rabbit Eye Tissue Cultures Infected with Herpes Simplex Virus . Invest. Ophthalmol. Vis. Sci. 1970;9(11):857-864.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The induction of the interferon mechanism in rabbit corneal, conjunctival, iris, and kidney tissue cultures with polyinosinic-polycytidylic acid complex protects against infections with herpes simplex virus. The degree of protection is inversely proportional to the viral challenge dose and is significantly enhanced by the addition of neomycin. The potential application of these observations to ocular infections of man is considered.

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