November 1970
Volume 9, Issue 11
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Articles  |   November 1970
Pathogenesis of Radiation-Induced Retinal Dysplasia
Author Affiliations
  • JAMES N. SHIVELY
    Collaborative Radiological Health Laboratory and the Departments of Anatomy and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colo.
  • ROBERT D. PHEMISTER
    Collaborative Radiological Health Laboratory and the Departments of Anatomy and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colo.
  • GLENWOOD P. EPLING
    Collaborative Radiological Health Laboratory and the Departments of Anatomy and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colo.
  • RUE JENSEN
    Collaborative Radiological Health Laboratory and the Departments of Anatomy and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colo.
Investigative Ophthalmology & Visual Science November 1970, Vol.9, 888-900. doi:
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      JAMES N. SHIVELY, ROBERT D. PHEMISTER, GLENWOOD P. EPLING, RUE JENSEN; Pathogenesis of Radiation-Induced Retinal Dysplasia. Invest. Ophthalmol. Vis. Sci. 1970;9(11):888-900.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The susceptibility of the maturing retina to damage by exposure to ionizing radiation has been known for a long time. However, details of both the early response to radiation and changes occurring several months after exposure have not been previously described. In the present study retinal dysplasia in dogs, irradiated as neonates, resulted from a sequence which included necrosis, lysis, migration, ectopic mitosis, and tubule formation. Continuing necrosis of cells in the dysplastic neural retina for as long as six months after irradiation ultimately produced atrophic changes.

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