February 1966
Volume 5, Issue 1
Free
Articles  |   February 1966
The Development of Enzyme Activities in Corneal Connective Tissue Cells During the Lag Phase of Wound Repair: II. Formalin-Resistant Oxidase-Like Reaction
Author Affiliations
  • VIRGINIA L. WEIMAR
    John E. Weeks Memorial Laboratory, Department of Ophthalmology, University of Oregon Medical School, Portland, Ore.
  • KENNETH H. HARAGUCHI
    John E. Weeks Memorial Laboratory, Department of Ophthalmology, University of Oregon Medical School, Portland, Ore.
Investigative Ophthalmology & Visual Science February 1966, Vol.5, 14-21. doi:
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      VIRGINIA L. WEIMAR, KENNETH H. HARAGUCHI; The Development of Enzyme Activities in Corneal Connective Tissue Cells During the Lag Phase of Wound Repair: II. Formalin-Resistant Oxidase-Like Reaction. Invest. Ophthalmol. Vis. Sci. 1966;5(1):14-21.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A formalin-resistant oxidase-like reaction which is cyanide- and phenylhydrazine-sensitive, but azide insensitive, develops intense activity in corneal endothelial, epithelial, and connective tissue cells within 24 hours after injury to the rat cornea. This apparently new oxidase-like system cannot be detected in the normal cornea. It attains maximal activity between 24 and 48 hours after injury and disappears between the fourth and seventh postoperative days. No cytochrome oxidase activity could be demonstrated in either the normal or in the healing cornea.

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