February 1966
Volume 5, Issue 1
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Articles  |   February 1966
The Effects of Detachment of the Retina on the Induced and Resting Ocular Potentials in the Rabbit
Author Affiliations
  • W. S. FOULDS
    Department of Ophthalmology, University of Glasgow, Glasgow, Scotland, and the Department of Experimental Ophthalmology, University of London, London, England
  • HISAKO IKEDA
    Department of Ophthalmology, University of Glasgow, Glasgow, Scotland, and the Department of Experimental Ophthalmology, University of London, London, England
Investigative Ophthalmology & Visual Science February 1966, Vol.5, 93-108. doi:
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    • Get Citation

      W. S. FOULDS, HISAKO IKEDA; The Effects of Detachment of the Retina on the Induced and Resting Ocular Potentials in the Rabbit. Invest. Ophthalmol. Vis. Sci. 1966;5(1):93-108.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Electrophysiologic investigations were carried out on rabbit eyes in which a total detachment of the retina had been induced. The latter is accompanied by a rapid reduction in the amplitude of the recorded b-wave of the electroretinogram with complete abolition of the ERG within 48 hours. These changes are paralleled by degenerative changes in the retinal receptor cells. Retinal separation is accompanied by a reduction in the total corneofundal potential and abolition of the light rise in the electrooculogram. In animals with a long-standing detachment of the retina intravenous sodium azide causes an increase in corneofundal potential after all light-induced changes in potential have been abolished, provided the pigment epithelium remains histologically normal. The techniques used are described and the significance of the findings discussed.

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