April 1966
Volume 5, Issue 2
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Articles  |   April 1966
Quantitative Study of Pupil Response to Miotic Drugs
Author Affiliations
  • Kenneth N. Ogle
    Mayo Clinic and Mayo Foundation, Section of Biophysics (Dr. Ogle and Mrs. Hazelrig), and the Mayo Graduate School of Medicine (University of Minnesota) (Dr. Whisnant) Rochester, Minn.
  • Robert A. Whisnant
    Mayo Clinic and Mayo Foundation, Section of Biophysics (Dr. Ogle and Mrs. Hazelrig), and the Mayo Graduate School of Medicine (University of Minnesota) (Dr. Whisnant) Rochester, Minn.
  • Jane B. Hazelrig
    Mayo Clinic and Mayo Foundation, Section of Biophysics (Dr. Ogle and Mrs. Hazelrig), and the Mayo Graduate School of Medicine (University of Minnesota) (Dr. Whisnant) Rochester, Minn.
Investigative Ophthalmology & Visual Science April 1966, Vol.5, 176-185. doi:
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      Kenneth N. Ogle, Robert A. Whisnant, Jane B. Hazelrig; Quantitative Study of Pupil Response to Miotic Drugs. Invest. Ophthalmol. Vis. Sci. 1966;5(2):176-185.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A model by which the time relationship of the miotic effects of three drugs (pilocarpine, eserine, and carbachol) can be described is discussed in a two compartment analysis. The data obtained on six subjects were subjected to a curve-fitting procedure with a computer, from which the parameters of the equation describing the miosis-time curve could be obtained. With these the pertinent characteristics of the responses to the drugs coidd be compared

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