December 1963
Volume 2, Issue 6
Free
Articles  |   December 1963
Factors Limiting Glycolysis in the Rat Lens
Author Affiliations
  • JOHN W. PATTERSON
    Department of Physiology, Vanderbilt University, School of Medicine, Nashville, Tenn.
  • KENNETH W. BUNTING
    Department of Physiology, Vanderbilt University, School of Medicine, Nashville, Tenn.
Investigative Ophthalmology & Visual Science December 1963, Vol.2, 612-616. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      JOHN W. PATTERSON, KENNETH W. BUNTING; Factors Limiting Glycolysis in the Rat Lens. Invest. Ophthalmol. Vis. Sci. 1963;2(6):612-616.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Glycolysis has been studied in extracts of rat lens with different concentrations of ATP and AMP as cofactors and various intermediates as substrates.

With optimal concentrations of cofactors, lactate fonnation from glucose approximates that obtained toith equivalent concentrations of pyruvate.

The activity found in extracts is much greater than that observed for the intact lens, so that an enzyme as such is not the limiting factor in lens glycolysis.

With varying cofactor concentrations, steps associated with different enzymes may be limiting. The step associated with hexokinase, 3-phosphoglyceric kinase, or glyceraldehyde phosphate dehydrogenase may be limiting under appropriate circumstances.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×