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Juan Pablo Davila, Abel Ramirez, Atzin Robles, ; TNF-Α PRESENT IN PROLIFERATIVE VITREORETINOPATHY SECONDARY TO RHEGMATOGENOUS RETINAL DETACHMENT. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1126.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the presence of proinflammatory cytokines, interleukins, TNF-α, IFN-γ in vitreous of patients with RRD without PVR, RRD with PVR and match them with its clinical stage.
Experimental , cross-sectional, comparative, prospective for quantification of IL2, IL4 , IL6, IL10 , TNF - α , IFN - γ Study in vitreous samples of 13 controls (RRD) , 3 (PVR A), 5 (PVR B), 4 (PVR C) with flow cytometry.
All groups showed activation of IL -2, average control group (CG) 9.02pg/mL against 9.45pg/mL in study groups. IL -4, CG 6.53pg/mL against (GroupA : 5.75pg/mL , 6.40pg/mL Group B , Group C 7.21pg/mL), although no statistical significance was shown with an upward trend in PVR. Concentration of IL-6 and IL-10 is present in all groups and was not statistically significant. The final concentration of TNF - α, in CG against all study groups (p> 0.05) , PVR A against PVR C (p> 0.05), PVR A versus PVR B (p> 0.05), between group B and C, no statistically significant difference was obtained.
This study observed an increase of TNF-α in PVR grades. An expansion the sample is required to identify TNF-α as responsible for the genesis of PVR.
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