April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
TNF-Α PRESENT IN PROLIFERATIVE VITREORETINOPATHY SECONDARY TO RHEGMATOGENOUS RETINAL DETACHMENT
Author Affiliations & Notes
  • Juan Pablo Davila
    Hosp Fdtn Nuestra Senora De La Luz, Mexico, Mexico
  • Abel Ramirez
    Hosp Fdtn Nuestra Senora De La Luz, Mexico, Mexico
  • Atzin Robles
    Hosp Fdtn Nuestra Senora De La Luz, Mexico, Mexico
  • Footnotes
    Commercial Relationships Juan Pablo Davila, None; Abel Ramirez, None; Atzin Robles, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1126. doi:
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      Juan Pablo Davila, Abel Ramirez, Atzin Robles, ; TNF-Α PRESENT IN PROLIFERATIVE VITREORETINOPATHY SECONDARY TO RHEGMATOGENOUS RETINAL DETACHMENT. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1126.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine the presence of proinflammatory cytokines, interleukins, TNF-α, IFN-γ in vitreous of patients with RRD without PVR, RRD with PVR and match them with its clinical stage.

 
Methods
 

Experimental , cross-sectional, comparative, prospective for quantification of IL2, IL4 , IL6, IL10 , TNF - α , IFN - γ Study in vitreous samples of 13 controls (RRD) , 3 (PVR A), 5 (PVR B), 4 (PVR C) with flow cytometry.

 
Results
 

All groups showed activation of IL -2, average control group (CG) 9.02pg/mL against 9.45pg/mL in study groups. IL -4, CG 6.53pg/mL against (GroupA : 5.75pg/mL , 6.40pg/mL Group B , Group C 7.21pg/mL), although no statistical significance was shown with an upward trend in PVR. Concentration of IL-6 and IL-10 is present in all groups and was not statistically significant. The final concentration of TNF - α, in CG against all study groups (p> 0.05) , PVR A against PVR C (p> 0.05), PVR A versus PVR B (p> 0.05), between group B and C, no statistically significant difference was obtained.

 
Conclusions
 

This study observed an increase of TNF-α in PVR grades. An expansion the sample is required to identify TNF-α as responsible for the genesis of PVR.

  
Keywords: 655 proliferative vitreoretinopathy • 697 retinal detachment • 688 retina  
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