April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Predictive value of outer retina Enface OCT imaging in geographic atrophy progression
Author Affiliations & Notes
  • Audrey Giocanti-Auregan
    Ophthalmology, Avicenne Hospital, Bobigny, France
  • Pauline Dourmad
    Centre d'imagerie et de Laser, Paris, France
  • Ramin Tadayoni
    Lariboisiere Hospital, Paris, France
  • Stephanie Magazzeni
    Carl Zeiss Meditec, Paris, France
  • Salomon Y Cohen
    Centre d'imagerie et de Laser, Paris, France
    Lariboisiere Hospital, Paris, France
  • Footnotes
    Commercial Relationships Audrey Giocanti-Auregan, None; Pauline Dourmad, None; Ramin Tadayoni, None; Stephanie Magazzeni, Carl Zeiss Meditec France (E); Salomon Cohen, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1240. doi:
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      Audrey Giocanti-Auregan, Pauline Dourmad, Ramin Tadayoni, Stephanie Magazzeni, Salomon Y Cohen; Predictive value of outer retina Enface OCT imaging in geographic atrophy progression. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1240.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

There is currently no good test available to predict progression of geographic atrophy (GA). The purpose of this study was to assess whether there was a correlation between hypo reflectivity (HR) of outer retina Enface OCT at baseline, and GA one year later in dry age-related macular degeneration (AMD).

 
Methods
 

We retrospectively included data from all patients who underwent a clinical examination for dry AMD from July to November 2013 and who had macular Enface OCT (Cirrus 2, Carl Zeiss Meditec, Inc, Dublin) follow-up of 2 years in a row. Eyes with previously treated wet AMD were excluded. For each patient, we assessed the size of HR and GA. Size of HR was assessed on extractions of outer retina 20 μm above retinal pigmented epithelium (RPE) corresponding to the ellipsoid line, and size of GA on extractions below RPE at each time point. Other outcomes assessed were sex, age, best-corrected visual acuity (BCVA) on ETDRS scale, fovea involvement in GA, speed of progression of GA, grading on visual analogic scale comparing the pattern of HR at baseline to the pattern of GA one year later, assessed independently by 2 retinal physicians (SYC, AGA). Our endpoint was the correlation between HR area at baseline and GA one year later. ImageJ software was used for area quantification.

 
Results
 

38 eyes of 31 patients (5 men, and 26 women) were included. At baseline, mean values were: age 84.9 years, size of GA area 7.1 mm2, size of HR 9.28 mm2, BCVA 64.2 letters, and fovea involvement in GA in 49% of cases. One year later, mean values were: size of GA area 9.2 mm2, size of HR 11mm2, BCVA 58.8 letters and fovea involvement in 54% of cases. The speed of progression of GA was 2.04 mm2 per year. The Pearson coefficient between the size of HR on Enface OCT at baseline and the size of GA one year later was 0,73. Enface OCT pattern was correlated in more than 2/3rd of cases (68.08%) with pattern of GA 1 year later: completely in 25.53% of cases, and partially in 42.55% of cases.

 
Conclusions
 

Enface OCT with extractions 20 microns above RPE may be an early indicator for detection of GA and its progression. In our series, the pattern and the size of HR on Enface OCT extractions seem correlated in some cases to the size and pattern of GA 1 year later.

 
Keywords: 412 age-related macular degeneration • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 550 imaging/image analysis: clinical  
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