April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Relationship Between Microperimetry and Goldmann Visual Field Variability In Retinitis Pigmentosa
Author Affiliations & Notes
  • Siegfried Karl Wagner
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Jasleen Kaur Jolly
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Markus Groppe
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Florian Gekeler
    Klinikum Stuttgart, Stuttgart, Germany
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
  • Andrew Webster
    Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Susan M Downes
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
  • Robert E MacLaren
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Footnotes
    Commercial Relationships Siegfried Wagner, None; Jasleen Jolly, None; Markus Groppe, None; Florian Gekeler, None; Andrew Webster, None; Susan Downes, None; Robert MacLaren, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1395. doi:
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      Siegfried Karl Wagner, Jasleen Kaur Jolly, Markus Groppe, Florian Gekeler, Andrew Webster, Susan M Downes, Robert E MacLaren, ; Relationship Between Microperimetry and Goldmann Visual Field Variability In Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1395.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Reliable testing of visual sensitivity in patients with retinitis pigmentosa (RP) has been reported using both microperimetry (MP) and Goldmann perimetry (GVF) for central and peripheral visual fields respectively. However, the relationship between the two tests in evaluating changes in visual function in patients with RP has not been characterized.

Methods: Twelve participants with an established diagnosis of RP were recruited into a multicentre clinical trial assessing the efficacy of transcorneal electrical stimulation for RP (NCT01847365). Participants underwent weekly treatment of one eye, retaining the other eye as a control. Visual field testing with MP and GVF analysis was performed on both eyes at baseline and after three months. Statistical analysis was performed using Spearman rank correlation coefficient.

Results: GVF analysis demonstrated marked peripheral field constriction, typical of RP, on all participants at baseline. MP was reliably performed utilising foveal fixation at baseline. A range of defects were apparent, with most participants displaying reduced retinal sensitivity in the central 10 degrees.

Conclusions: Both MP and GVF are useful measures of visual function in patients with RP. In advanced cases, MP has the advantage of targeting specific central areas, which cannot be mapped accurately with GVF. Using both measures is more effective at monitoring changes in interventional trials and disease progression than using each test alone.

Keywords: 696 retinal degenerations: hereditary • 758 visual fields • 468 clinical research methodology  
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