April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Progressive Expansion of the Hyperautofluorescent Ring in Cone-Rod Dystrophy
Author Affiliations & Notes
  • Luiz Henrique Lima
    Ophthalmology, Federal University of Sao Paulo-UNIFESP, Sao Paulo, Brazil
  • Juliana M F Sallum
    Ophthalmology, Federal University of Sao Paulo-UNIFESP, Sao Paulo, Brazil
  • Vivienne C Greenstein
    Ophthalmology, Columbia University, New York, NY
  • Stephen H Tsang
    Ophthalmology, Columbia University, New York, NY
  • Footnotes
    Commercial Relationships Luiz Lima, None; Juliana Sallum, None; Vivienne Greenstein, None; Stephen Tsang, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1419. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Luiz Henrique Lima, Juliana M F Sallum, Vivienne C Greenstein, Stephen H Tsang; Progressive Expansion of the Hyperautofluorescent Ring in Cone-Rod Dystrophy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1419.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To demonstrate progressive expansion of the hyperautofluorescent ring and changes in retinal structure in patients with cone-rod dystrophy (CRD), using fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT)

 
Methods
 

Twenty eyes of 20 CRD patients with a hyperautofluorescent ring were studied. Ring expansion was evaluated by measurements of its external and internal boundaries along the vertical and horizontal axes at baseline, 12 and 24 month follow-ups. FAF was obtained at 12 and 24 in all study eyes. SD-OCT images were obtained on all study eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measured. SD-OCT was repeated at 12 and 24 month follow-ups

 
Results
 

The external boundaries of the ring were identified along both the horizontal axis and the vertical axis in all study eyes. Internal boundaries were identified in all study eyes. Expansion of the hyperautofluorescent ring was demonstrated in all patients. SD-OCT measurements showed a decrease in the IS/OS junction length

 
Conclusions
 

There was evidence of ring expansion in all CRD patients along most meridians associated with a loss of the IS/OS junction lamina temporal and nasally to the fovea. Therefore, FAF and SD-OCT may be important non-invasive imaging techniques to monitor CRD patients.

     
Keywords: 688 retina • 550 imaging/image analysis: clinical • 494 degenerations/dystrophies  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×