April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Correlation between polarization sensitive optical coherence tomography and microperimetry in Retinitis Pigmentosa
Author Affiliations & Notes
  • Karin Kofler
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Christopher Schütze
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Bernhard Baumann
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Stefan Zotter
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Philipp Ken Roberts
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Markus Ritter
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Christoph K Hitzenberger
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Karin Kofler, None; Christopher Schütze, None; Bernhard Baumann, Canon Inc. (F); Stefan Zotter, Canon Inc. (F); Philipp Roberts, Canon Inc. (F); Michael Pircher, Canon Inc. (F); Markus Ritter, None; Christoph Hitzenberger, Canon Inc. (C), Canon Inc. (F); Ursula Schmidt-Erfurth, Alcon (C), Bayer (C), Novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1624. doi:
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      Karin Kofler, Christopher Schütze, Bernhard Baumann, Stefan Zotter, Philipp Ken Roberts, Michael Pircher, Markus Ritter, Christoph K Hitzenberger, Ursula Schmidt-Erfurth; Correlation between polarization sensitive optical coherence tomography and microperimetry in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1624.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Retinitis pigmentosa (RP) is a clinical and genetic heterogenic group of retinal diseases affecting rods and cones. There is also a strong involvement of the retinal pigment epithelium (RPE) in the pathophysiologic process in RP. To get new insights into the relation between this important layer and the retinal function we correlated the integrity of the RPE by using polarization sensitive optical coherence tomography (PS-OCT) with the retinal sensitivity.

Methods: Twenty-one eyes of eleven patients with RP were imaged using a prototype PS OCT device. The area of preserved retinal sensitivity (AOPRS) was evaluated by using microperimetry (Nidek MP1). Images of these two techniques were overlayed and compared. For the data analysis a grading system was developed. Eyes with a clearly overlapping RPE compared to the AOPRS were graded with 2, whereas eyes with slightly overlapping RPE were graded with 1. Eyes where the AOPRS clearly overlapped the RPE were graded with -2. Eyes with slightly overlapping AOPRS where graded with -1. The quality of RPE integrity was assessed with a scale from 1 to 3 (1 very good integrity, 3 poor quality).

Results: In eighteen eyes the RPE overlapped the AOPRS. Thirteen eyes were graded with 2, five eyes with 1. In two eyes the AOPRS clearly overlapped the RPE and were graded with -2. In one eye the RPE on the nasal side was graded with -1 and on the temporal side with 2. In twelve eyes the integrity of the RPE inside the AOPRS was graded with 1, in eight eyes with 2 and in one eye with 3.

Conclusions: PS-OCT is capable of detecting the integrity of the RPE in cases of RP. This is the first study correlating RPE integrity assessed by PS-OCT and retinal sensitivity. Based on this technique and the correlation with retinal function new insight into the condition of the RPE in the progression of RP can be gained.

Keywords: 701 retinal pigment epithelium • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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