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Yosuke Nagasaka, Yasuki Ito, Shinji Ueno, Hiroko Terasaki, ; Inner retinal layer thickness in eyes with retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1725.
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© ARVO (1962-2015); The Authors (2016-present)
Retinitis pigmentosa (RP) is a disease that causes photoreceptor degeneration and loss of photoreceptors. Reduction of retinal thickness due to outer retinal layer loss was known, but the thickness of inner retina of RP has not been elucidated. Several studies reported the thickness of inner retina was thicker than that of normal control but the thickness of each layer in inner retina has not been investigated. In this study, we have evaluated inner retinal thickness in eyes of RP using spectral domain optical coherence tomography (SD-OCT).
SD-OCT images (Spectralis, Heidelberg Engineering, Heidelberg, Germany) of 57 eyes of 29 patients of retinitis pigmentosa (50.6±15.0 years) were analyzed. Thickness of total neural retina, nerve fiver layer (NFL), ganglion cell layer (GCL), inner plexiform layer (IPL) , inner nuclear layer (INL) and other outer layers were measured at the 1 and 2 mm superior, inferior, nasal, or temporal to the fovea in 9 mm vertical and horizontal scan. As a control, same measurements were performed in 13 normal eyes of 13 age-matched subjects (51.6±9.7 years). Average thickness of total neural retina and each layers of these 8 points were compared between RP patients and normal controls.
The average thickness of the total neural retina of RP patients was 283.9±49.9µm and was significantly thinner than that of normal controls of 322.8±23.2µm (p<0.01). The average NFL thickness of RP patients and normal controls were 40.3±7.9 µm and 30.2±4.0 µm respectively. The GCL thickness of RP patients and normal controls were 56.8±11.5 µm and 47.8±8.1 µm respectively. The NFL and GCL thickness were significantly thicker in RP eyes than normal eyes (p<0.001 and p<0.01 respectively). The IPL thickness of RP patients and normal controls were 33.7±4.7 µm and 34.6±3.0 µm respectively and were not significantly different (p>0.05). The INL thickness of RP and normal controls were 48.0±7.2 µm and 40.5±5.0 µm respectively. The INL thickness were significantly thicker in RP eyes than normal eyes (p<0.001). Thickness of other outer layers of RP patients was 105.0±36.4 µm and was significantly thinner than normal eyes of 169.7.0±9.8 µm (p<0.001).
Not only NFL and GCL thickness but also INL thickness become thicker than normal controls in RP eyes. In eyes of RP patients, inner retinal layers become thicker except for IPL.
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