April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Pupil responses to selective wavelength (colored) light stimulation in healthy and retinal degenerate mice
Author Affiliations & Notes
  • Corinne Kostic
    Dept Ophthalmology, Univ Lausanne, Jules-Gonin Eye Hosp, Lausanne, Switzerland
  • Sylvain Crippa
    Dept Ophthalmology, Univ Lausanne, Jules-Gonin Eye Hosp, Lausanne, Switzerland
  • Catherine Martin
    Dept Ophthalmology, Univ Lausanne, Jules-Gonin Eye Hosp, Lausanne, Switzerland
  • Randy H Kardon
    Dept Ophthalmology and Visual Science, University of Iowa Hospitals and Clinics, Iowa, IA
  • Yvan Arsenijevic
    Dept Ophthalmology, Univ Lausanne, Jules-Gonin Eye Hosp, Lausanne, Switzerland
  • Aki Kawasaki
    Dept Ophthalmology, Univ Lausanne, Jules-Gonin Eye Hosp, Lausanne, Switzerland
  • Footnotes
    Commercial Relationships Corinne Kostic, None; Sylvain Crippa, None; Catherine Martin, None; Randy Kardon, None; Yvan Arsenijevic, None; Aki Kawasaki, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1726. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Corinne Kostic, Sylvain Crippa, Catherine Martin, Randy H Kardon, Yvan Arsenijevic, Aki Kawasaki; Pupil responses to selective wavelength (colored) light stimulation in healthy and retinal degenerate mice. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1726.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Different light stimulus conditions were used to characterize the pupillary light reflex (PLR) in different mouse models.

Methods: Sv129 mice, Rho-/- and CNGA3-/- were subjected to short stimuli of increasing intensity of red and blue light alternatively. The PLR was recorded using the A2000 Neuroptics system. Maximal contraction amplitudes as well as recovery phase were compared between the different models.

Results: In wild type mice, increasing intensity of blue light produced prolongation of the pupil contraction and a distinctive change in the pupil response waveforms, particularly post-stimulus recovery. Additionally the duration of dark adaptation influenced both amplitude and recovery of the PLR. In comparison, Rho-/- mice showed decreased pupil responses to all blue and red light stimuli except the highest intensity blue stimulus. Pupil responses of CNGA3-/- to blue or red light were similar to those of wild type mice.

Conclusions: Loss of photoreceptors differentially affects the PLR to light stimuli of different wavelengths and intensity.

Keywords: 668 pupillary reflex • 696 retinal degenerations: hereditary • 649 photoreceptors: visual performance  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×