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Liz Julieth Zapata, Yasir Sepah, Jose Maya, Mostafa Saad Hanout, Mohammad Ali Sadiq, Salman Sarwar, Nithya Rajagopalan, Kathleen Ellen Guinn, Quan Dong Nguyen, Diana V Do, ; Vascular changes in the macula of eyes with diabetic macular edema treated with varying doses of ranibizumab. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1748.
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The aim of this study is to assess the changes in vessel diameter in the macula of patients with diabetic macular edema (DME) treated with 2 different doses of ranibizumab (RBZ).
Fundus photos from 38 patients (38 eyes) enrolled in the READ-3 study (comparison of 0.5mg vs. 2.0mg of RBZ for DME) were analyzed. Photos were divided in two groups according to treatment arms (Group A=0.5mg; Group B=2.0mg). All eyes received 6 monthly injections starting at the baseline visit. Macular retinal arterial equivalent (MRAE) and macular retinal venular equivalent (MRVE) were measured using Interactive Vessel Analysis (IVAN) software centered on the fovea; the 2 largest venules and arterioles one-half to one disc diameter from the fovea were measured. Parametric tests (paired t-test, independent t-test) were performed to compare the MRVE and MRAE between the two groups.
17 patients were included in group A; 21 in group B. The mean age was 62 and 64 in group A and B, respectively. 10 patients were male in group A; 13 males in group B. There was reduction in both MRAE and MRVE at month 6 compared to baseline for both doses of RBZ (table). The changes were statistically significant in MRVE and demonstrated a trend towards significance in MRAE. However, the changes (MRAE and MRVE) that occurred in group A were similar to those in group B and did not demonstrate any statistically significant differences (p=0.210 for MRAE and p=0.614 for MRVE).
Treatment of DME with RBZ appears to induce similar reduction in MRVE and MRAE, regardless of dose. Such findings with fovea-centered vascular grading imply that low and high dose of RBZ may have similar effects on macular vasculature in eyes with DME.
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