April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal vascular changes in eyes with diabetic macular edema treated with different doses of ranibizumab
Author Affiliations & Notes
  • Jose Maya
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Yasir Sepah
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Liz Julieth Zapata
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Mostafa Saad Hanout
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Mohammad Ali Sadiq
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Salman Sarwar
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Kathleen Ellen Guinn
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Nithya Rajagopalan
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Diana V Do
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Quan Dong Nguyen
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Unviersity of Nebraska Medical Center, Omaha, NE
  • Footnotes
    Commercial Relationships Jose Maya, None; Yasir Sepah, None; Liz Zapata, None; Mostafa Hanout, None; Mohammad Sadiq, None; Salman Sarwar, None; Kathleen Guinn, None; Nithya Rajagopalan, None; Diana Do, Genentech (F), Regeneron (F); Quan Dong Nguyen, Genentech (F), Regeneron (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1766. doi:
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    • Get Citation

      Jose Maya, Yasir Sepah, Liz Julieth Zapata, Mostafa Saad Hanout, Mohammad Ali Sadiq, Salman Sarwar, Kathleen Ellen Guinn, Nithya Rajagopalan, Diana V Do, Quan Dong Nguyen, ; Retinal vascular changes in eyes with diabetic macular edema treated with different doses of ranibizumab. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1766.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

The aim of this study is to assess the changes in vessel diameter in patients with diabetic macular edema (DME) treated with 2 different doses of ranibizumab (RBZ).

 
Methods
 

Fundus photos from 55 patients (55 eyes) enrolled in the READ-3 study (comparison of 0.5mg VS 2.0mg of RBZ for DME) were analyzed. Photos were divided into two groups according to the treatment arm (Group A=0.5mg; Group B=2.0mg). All eyes received 6 monthly injections starting at baseline visit. Central retinal arterial equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured using Interactive Vessel Analysis (IVAN) software, ½ disc diameter to 1 disc diameter from the margin of the optic disc, in 6 largest venules and arterioles. Parametric tests (paired t-test, independent t-test) were performed to compare the CRVE and CRAE between the two groups.

 
Results
 

26 patients were included in group A; 29 in group B. The mean age was 63 and 65 in group A and B, respectively. 14 patients were males in group A; 17 males in group B. There was reduction in both CRAE and CRVE at month 6 compared to baseline for both doses of RBZ (table). The changes were statistically significant in CRVE and demonstrated a trend towards significance in CRAE. However, inter-comparison did not demonstrate any statistically significant differences between the two dose groups.

 
Conclusions
 

Treatment of DME with RBZ appears to induce similar reduction in CRVE and CRAE regardless of the dose. Such findings imply that low and high dose of RBZ may have similar effects on retinal vasculature in eyes with DME.

  
Keywords: 436 blood supply • 505 edema • 499 diabetic retinopathy  
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