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ora levy, Franck Fajnkuchen, Benjamin Penaud, Gilles Chaine, Audrey Giocanti-Auregan; Impact of summer follow-up interruption on functional and anatomical results over the course of Ranibizumab treatment for Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1774.
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Ranibizumab Intravitreal injections (IVT) improve Best Corrected Visual Acuity (BCVA) and lower Central Foveal Thickness (CFT) in Diabetic Macular Edema (DME). This treatment requires a monthly follow-up. Nevertheless, a long period of follow-up interruption can occur during summer break. The purpose of this study was to evaluate whether this period actually impacts on BCVA and CFT over the course of DME treatment.
We included in a retrospective fashion all patients with DME over the course of Ranibizumab injections from April to October 2013 with good anatomical and functional results after 3 initial IVT followed by a pro re nata strategy. We have included all patients who were neither followed nor injected during at least 7 consecutive weeks. 2 outcomes were assessed : BCVA (ETDRS scale) and CFT on spectral domain OCT, (OPKO, Optos, Dunfermline, Scotland) before and after the break.
We have included 12 eyes of 11 patients (6 women, 5 men) who stopped their follow-up for at least 7 weeks. Mean age was 61.8 years, mean duration of break was 12 weeks (from 7.1 to 26 weeks). Patients underwent an average of 4 IVT and were treated for 5.7 months before the summer break. All patients came back to follow-up after the break. When the patients were back to follow-up, mean decrease in BCVA was -3.6 letters (from +8 to -22 letters) and mean increase in CFT was +209 microns (from -200µm to +920 µm).
3 months of break in follow-up generally due to summer holiday, does not seem to have irreversible consequences on functional results in DME treatment. In this case series, the break of follow-up has widely increased CFT while it did not significantly impact BCVA. This fact underlines the weak correlation between anatomical and functional results over the course of DME treatment.
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