April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Evaluation Of The Diagnostic Properties Of Wide-field Fundusautofluorescence Imaging And Two Laser Wavelenghth Scanning Laser Ophthalmoscopy In Differentiation Of Choroidal Pigmented Lesions
Author Affiliations & Notes
  • Sarah Thiele
    University Eye Hospital of the Ludwig Maximilians University, Munich, Germany
  • Lukas Reznicek
    University Eye Hospital of the Ludwig Maximilians University, Munich, Germany
  • Florian Seidensticker
    University Eye Hospital of the Ludwig Maximilians University, Munich, Germany
  • Carmen Stumpf
    University Eye Hospital of the Ludwig Maximilians University, Munich, Germany
  • Anselm Kampik
    University Eye Hospital of the Ludwig Maximilians University, Munich, Germany
  • Aljoscha S Neubauer
    University Eye Hospital of the Ludwig Maximilians University, Munich, Germany
  • Marcus Kernt
    University Eye Hospital of the Ludwig Maximilians University, Munich, Germany
  • Footnotes
    Commercial Relationships Sarah Thiele, None; Lukas Reznicek, None; Florian Seidensticker, None; Carmen Stumpf, None; Anselm Kampik, None; Aljoscha Neubauer, None; Marcus Kernt, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1794. doi:
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      Sarah Thiele, Lukas Reznicek, Florian Seidensticker, Carmen Stumpf, Anselm Kampik, Aljoscha S Neubauer, Marcus Kernt; Evaluation Of The Diagnostic Properties Of Wide-field Fundusautofluorescence Imaging And Two Laser Wavelenghth Scanning Laser Ophthalmoscopy In Differentiation Of Choroidal Pigmented Lesions. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1794.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the diagnostic properties of wide-field fundus autofluorescence (FAF) and wide-field scanning laser ophthalmoscope (SLO) imaging for differentiating pigmented choroidal lesions.

Methods: A consecutive series of 139 patients with clinically diagnosed melanocytic choroidal tumors were included. Out of those, 101 had established choroidal melanoma, of these, 12 were untreated lesions, 98 were treated with radiotherapy. Thirty eight had choroidal nevi. All patients underwent a full clinical ophthalmological examination, undilated Optomap 200Tx (Optos PLC, Dunfermline, Fife, Scotland, UK) wide-field imaging including wide-field FAF and standardized US examination. FAF images and imaging characteristics from the SLO were correlated with the structural findings in the two patient groups.

Results: 139 eyes with choroidal melanocytic lesions were included, 101 with established melanomas compared to 38 with confirmed choroidal nevi. Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. In “green laser separation”, a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal (minimal) transverse and longitudinal diameter of melanomas was significantly higher than of nevi. A regression analysis revealed a sensitivity of 88.2% and a specificity of 68.8% to correctly differentiate a choroidal melanoma from a nevus applying wide-field FAF and SLO imaging including the above mentioned criteria.

Conclusions: Wide-field SLO and FAF imaging may be an appropriate non-invasive and non-mydriatic diagnostic screening tool with high accuracy to differentiate benign from malign pigmented choroidal lesions.

Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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