April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
The effect of the locations of reference electrodes on the electrical evoked potentials elicited by suprachoroidal-transretinal stimulation in rabbit eye.
Author Affiliations & Notes
  • Kentaro Nishida
    Department of Ophthalmology, Sakai City Hospital, Sakai, Sakai, Japan
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Hirokazu Sakaguchi
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Motohiro Kamei
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Takashi Fujikado
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Kohji Nishida
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Footnotes
    Commercial Relationships Kentaro Nishida, None; Hirokazu Sakaguchi, None; Motohiro Kamei, None; Takashi Fujikado, None; Kohji Nishida, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1812. doi:
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      Kentaro Nishida, Hirokazu Sakaguchi, Motohiro Kamei, Takashi Fujikado, Kohji Nishida; The effect of the locations of reference electrodes on the electrical evoked potentials elicited by suprachoroidal-transretinal stimulation in rabbit eye.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1812.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine the effect of the locations of reference electrodes on the electrical evoked potentials (EEPs) elicited by suprachoroidal-transretinal stimulation (STS) in rabbit eye.

 
Methods
 

A scleral pocket (3x5 mm) was created just over the visual streak in anesthetized rabbits (weight, 2.2-2.5 kg). The STS stimulating electrode system was implanted into the pocket. Three reference electrodes were implanted in the three different locations (the vitreous cavity; Group A, the sclera opposite to the stimulating electrode; Group B, and the sclera near the stimulating electrode; Group C) . EEPs were then elicited by each location of reference electrodes. Three sessions were repeated for each condition.

 
Results
 

The implicit times of the EEPs were 25.4±0.3 ms (Group A), 24.2±0.6 ms (Group B), and 26.5±5.4 ms (Group C) , and the amplitudes were 48.2±15.6 µV (Group A), 21.0±5.9 µV(Group B) and 12.7±6.4 µV(Group C) respectively. These differences in implicit time of EEPs were not significant (P>0.05). The amplitude of the EEPs in Group A was significantly larger the those of the other two Groups (P<0.001).

 
Conclusions
 

The reference electrode in the vitreous cavity seems to be most effective in suprachoroidal-transretinal stimulation.

     
Keywords: 688 retina • 508 electrophysiology: non-clinical • 755 visual cortex  
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