April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Correlation between stress, cytokines and uveitic activity in patients with anterior uveitis
Author Affiliations & Notes
  • Stephanie Voorduin
    Ocular Inflammatory Diseases Department, Fundación Hospital Nuestra Señora de la Luz, Mexico, Mexico
  • Judith Almada
    Ocular Inflammatory Diseases Department, Fundación Hospital Nuestra Señora de la Luz, Mexico, Mexico
  • Francisco Martínez
    Ocular Inflammatory Diseases Department, Fundación Hospital Nuestra Señora de la Luz, Mexico, Mexico
  • Milton Maldonado
    Ocular Inflammatory Diseases Department, Fundación Hospital Nuestra Señora de la Luz, Mexico, Mexico
  • Teresa Valdez
    Ocular Inflammatory Diseases Department, Fundación Hospital Nuestra Señora de la Luz, Mexico, Mexico
  • Gustavo Aguilar
    Ocular Inflammatory Diseases Department, Fundación Hospital Nuestra Señora de la Luz, Mexico, Mexico
  • Atzin Robles-Contreras
    Centro de Investigación Biomédica, Fundación Hospital Nuestra Señora de la Luz, Mexico, Mexico
  • Footnotes
    Commercial Relationships Stephanie Voorduin, None; Judith Almada, None; Francisco Martínez, None; Milton Maldonado, None; Teresa Valdez, None; Gustavo Aguilar, None; Atzin Robles-Contreras, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1863. doi:
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      Stephanie Voorduin, Judith Almada, Francisco Martínez, Milton Maldonado, Teresa Valdez, Gustavo Aguilar, Atzin Robles-Contreras, ; Correlation between stress, cytokines and uveitic activity in patients with anterior uveitis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1863.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To demonstrate the correlation between emotional stress, pro-inflammatory and anti-inflammatory cytokines in the activity of anterior uveitis.

Methods: An analytical, transversal, observational and prospective study was done including patients with autoimmune anterior uveitis. Patients were divided in two groups: active anterior uveitis (AAU) o inactive anterior uveitis (IAU) according to the SUN criteria. Five psychiatric stress tests (PST): Q-LES-Q, GHQ28, STAI, SASS and Sheehan were applied in all cases. Tear samples were obtained at the same time to measure pro-inflammatory cytokines IL-1beta, IL-6, IL-8, TNF-alpha, and the anti-inflammatory cytokines: IL-10 and IL-12p70 and these cytokines levels were determined by cytometric bead arrays. Data were analyzed with U Mann-Withney tests and Spearman correlation test.

Results: Fifteen AAU patients and 7 IAU patients were included. We found an increased statistical difference (p<0.05) in the levels of pro-inflammatory cytokines between AAU (IL-1beta: 17.01+/-20.49pg/ml, IL-6: 29.92+/-64.79pg/ml, IL-8: 240.9 +/- 178.9pg/ml), and IAU (IL-1beta: 3.87+/-8.71pg/ml, IL-6: 2.75+/-5.49pg/ml, IL-8: 121.9+/-38.25pg/ml). There was not statistical difference in levels of TNF-alpha, IL-10 and IL-12p70 between the two groups. In psychiatric tests there was a statistical difference (p<0.05) in all parameters related with stress between AAU and IAU. The correlation between levels of cytokines and the clinical score obtained from PST showed a statistical difference (p<0.05).

Conclusions: Increased levels of emotional stress in the AAU patients are correlated with increased levels of pro-inflammatory cytokines. There was no difference between anti-inflammatory cytokines. This study demonstrates the importance of the multidisciplinary approach in patients with AAU at least by ophthalmology and psychiatry specialist.

Keywords: 490 cytokines/chemokines • 746 uveitis-clinical/animal model • 726 stress response  
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