April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal Macular Volumes May Correlate with Serum VEGF Levels in Women with Severe Preeclampsia
Author Affiliations & Notes
  • Victoria North
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY
  • Huy V. Nguyen
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY
  • Aakriti Garg
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY
  • Serge Cremers
    Irving Institute for Clinical and Translational Research, Columbia University, New York, NY
  • Cande Ananth
    Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY
    Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, NY
  • Ronald J Wapner
    Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY
  • Rando Allikmets
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY
  • Srilaxmi Bearelly
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY
  • Footnotes
    Commercial Relationships Victoria North, None; Huy Nguyen, None; Aakriti Garg, None; Serge Cremers, None; Cande Ananth, None; Ronald Wapner, None; Rando Allikmets, None; Srilaxmi Bearelly, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1930. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Victoria North, Huy V. Nguyen, Aakriti Garg, Serge Cremers, Cande Ananth, Ronald J Wapner, Rando Allikmets, Srilaxmi Bearelly; Retinal Macular Volumes May Correlate with Serum VEGF Levels in Women with Severe Preeclampsia. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1930.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To compare serum levels of vascular endothelial growth factor (VEGF) between patients with severe preeclampsia (sPE) and normotensive postpartum controls using enzyme-linked immunosorbent assay (ELISA), and to determine whether VEGF levels correlate with retinal macular volumes in patients with sPE using enhanced depth imaging spectral domain optical coherence tomography (EDI SD-OCT).

Methods: This incident case-control study examined 12 women with sPE and 5 women with normotensive pregnancies who were age-matched (mean age 33.6 years ± 7.5 SD and mean age 32.6 years ± 8.0 SD, respectively). Nineteen eyes of women with sPE were included in the imaging portion of the analysis. Exclusion criteria included chronic or gestational hypertension without proteinuria, and diabetes. All subjects were recruited in the immediate postpartum period and underwent EDI SD-OCT imaging as well as blood draw. Heidelberg Eye Explorer software was used to automate retinal macular volume measurements. ELISA was used to measure serum VEGF in picograms (pg/ml).

Results: Mean serum VEGF in sPE was 319.5 pg/ml and in normotensive postpartum controls was 160.5 pg/ml (P = 0.2401). Mean retinal macular volume in sPE was 8.82 mm3 and in controls was 8.42 mm3 (P = 0.0004). Amongst cases, retinal macular volumes correlated with serum VEGF levels with a Pearson’s correlation coefficient of R = 0.44 (P = 0.0594).

Conclusions: Our results support the hypotheses that VEGF levels are increased in sPE as compared with normotensive postpartum controls, and that systemic VEGF levels may correlate with retinal thickening in the setting of sPE. This study is limited by the small number of subjects.

Keywords: 748 vascular endothelial growth factor • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 688 retina  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×