April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Dry Eye Disease Patients with Xerostomia Report Higher Symptomatic Burden
Author Affiliations & Notes
  • Ida Grunnan Fostad
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Norwegian Dry Eye Clinic, Oslo, Norway
  • Jon Roger Eidet
    Norwegian Dry Eye Clinic, Oslo, Norway
    Unit of Regenerative Medicine, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
  • Sten Ræder
    Norwegian Dry Eye Clinic, Oslo, Norway
  • Neil S Lagali
    Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
  • Edward B Messelt
    Department of Oral Biology, University of Oslo, Oslo, Norway
  • Janicke L Jensen
    Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway
  • Hilde K Galtung
    Department of Oral Biology, University of Oslo, Oslo, Norway
  • Darlene Dartt
    Schepens Eye Research Institute, Massachusetts Eye and Ear/Harvard Medical School, Boston, MA
  • Tor Paaske Utheim
    Norwegian Dry Eye Clinic, Oslo, Norway
    Unit of Regenerative Medicine, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
  • Footnotes
    Commercial Relationships Ida Fostad, None; Jon Roger Eidet, None; Sten Ræder, None; Neil Lagali, None; Edward Messelt, None; Janicke Jensen, None; Hilde Galtung, None; Darlene Dartt, None; Tor Utheim, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1995. doi:
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      Ida Grunnan Fostad, Jon Roger Eidet, Sten Ræder, Neil S Lagali, Edward B Messelt, Janicke L Jensen, Hilde K Galtung, Darlene Dartt, Tor Paaske Utheim; Dry Eye Disease Patients with Xerostomia Report Higher Symptomatic Burden. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1995.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED).

 
Methods
 

All patients with symptomatic DED who contacted the Norwegian Dry Eye Clinic, with or without a doctor’s referral, were consecutively included in the study. The patients underwent a comprehensive ophthalmological work-up and completed a self-questionnaire on symptoms of dry eyes (Ocular Surface Disease Index [OSDI]) and the Sjögren’s syndrome (SS) questionnaire (SSQ).

 
Results
 

Four hundred and thirty two patients (53% women and 47% men) with DED of different etiologies were included. Patient demographics were: 0 to 19 years (1%), 20 to 39 (25%), 40 to 59 (34%), 60 to 79 (35%) and 80 to 99 (5%). Xerostomia, defined as “daily symptoms of dry mouth the last three months” (as presented in SSQ) was reported by 23% of the patients. SS was previously diagnosed in 3% of the patients. Xerostomia was more prevalent in females (36%) than in males (9%; P<0.001), and was weakly correlated with age (R2=0.04; P<0.001) and polypharmacy (R2=0.06; P<0.001). Patients with xerostomia had a higher OSDI score (17.9 ±10.3) than those without xerostomia (13.0 ± 8.3; P<0.001). Moreover, xerostomia patients had lower meibum expressibility (P=0.022) and a higher intraocular pressure (IOP) (P=0.046) than those without xerostomia. Comparisons of OSDI, meibum expressibility and IOP between patients with/without xerostomia were made after controlling for the effects of gender, age and polypharmacy.

 
Conclusions
 

Dry eye disease patients with xerostomia report more DED symptoms and have a poorer meibum expressibility compared to those without xerostomia.

 
Keywords: 486 cornea: tears/tear film/dry eye  
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