April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Diagnostic performance of electrical ocular surface resistance for dry eye disease
Author Affiliations & Notes
  • Everardo Hernandez-Quintela
    Cornea Service, Association Para Evitar la Ceguera, Mexico City, Mexico
  • Nallely Ramos Betancourt
    Cornea Service, Association Para Evitar la Ceguera, Mexico City, Mexico
  • Alejandra Gonzalez-Dibildox
    Cornea Service, Association Para Evitar la Ceguera, Mexico City, Mexico
  • Manuel Ramirez
    Cornea Service, Association Para Evitar la Ceguera, Mexico City, Mexico
  • Footnotes
    Commercial Relationships Everardo Hernandez-Quintela, None; Nallely Ramos Betancourt, None; Alejandra Gonzalez-Dibildox, None; Manuel Ramirez, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2009. doi:
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    • Get Citation

      Everardo Hernandez-Quintela, Nallely Ramos Betancourt, Alejandra Gonzalez-Dibildox, Manuel Ramirez; Diagnostic performance of electrical ocular surface resistance for dry eye disease. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2009.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine the diagnostic performance of electrical ocular surface resistance (EOSR) for dry eye disease.

Methods: Thirty consecutive patients (30 eyes) were asked to complete an evaluation of dry eye signs and symptoms by the Ocular Surface Disease Index (OSDI) questionnaire, corneal staining with fluorescein, tear-film breakup time, and Schirmer’s test with anesthesia. EOSR was measured with two microelectrodes applied on the ocular surface. A total of 19 dry eye patients vs. 11 Non dry eye control group were compared. Mean age was 40.27 +/- 15.28 years old, 23 patients (76.7%) were female. Intra and inter-observer agreement were also analyzed.

Results: Mean EOSR for normal subjects was 191 +/- 12K Ohms and 260 +/- 146K Ohms for the dry eye patients. Seven cases with Sjogren syndrome showed a significantly higher EOSR (363 +/- 196 K Ohms). EOSR correlated significantly with dry eye severity grade symptoms (OSDI, r = 0.53). Intra-observer Intraclass Correlation Coefficient was 0.92 (95%CI, 0.81 - 0.95) and for inter-observer analysis was 0.67 (95% CI, 0.30 - 0.84).

Conclusions: The present study found a higher EOSR in patients with severe dry eye compared with healthy controls. Testing EOSR might be an effective alternative objective diagnostic tool for dry eye disease.

Keywords: 479 cornea: clinical science • 465 clinical (human) or epidemiologic studies: systems/equipment/techniques • 486 cornea: tears/tear film/dry eye  
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