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Emilio Almeida Torres Netto, Lucas Antonio Almeida Torres, Rogerio J Almeida Torres, Fernando Cesar Abib; The corneal specular microscopy study of the eyes submitted to drainage device implant with long time follow-up. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2074.
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© ARVO (1962-2015); The Authors (2016-present)
To know the corneal endothelial situation in long time follow-up of the patients submitted to drainage device (DD) even considering examinations with sample error smaller than 5% calculated by reliability indexes developed for specular microscopy (SM).
Retrospective study of the 12 eyes with glaucoma with difficult clinical control submitted to DD in the anterior chambre. The corneal endothelial was examined at the central area with contact specular microscopy Bio-Optics LSM 2000 and Bambi 2500 software. All examinations had the sample error smaller than 5% and calculated by Cells Analyzer Software - Corneal Endothelial Statistical Lab (Technicall, Brazil). The follow data, were related by descriptive statistic, from each patient: age; size of the endothelial samples, number of SM images/patient, follow-up time, minimum (MIN) endothelial cell density (ECD), maximum (MAX) ECD, mean ECD; MIN coefficient of variation (CV), MAX CV, mean CV; MIN percentage of hexagonal cells (%H), MAX %H, mean %H. With the results of the ECD and the time of the SM examinations during the follow-up the linear regression equation and model were calculated, with the specific equation for each clinical case, the theoretical maximum (Tmax) and theoretical minimum (Tmin) ECD were calculated. The endothelial cell loss per month and year was calculated using TMax minus TMin per period of the time (month and year). The GraphPad QuickCalcs were used to calculate the linear regression model and equation and Microsoft Excel 2010 to calculate the descriptive data.
The mean age were 61 years old. The size of the endothelial samples were: MIN SM per patient was 3, the MAX was 10 , and the mean was 5,5. The results of the ECD, CV and %H were reported at the Table 1. For all clinical cases the TMax and the TMin were described at the Table 2. For all clinical cases the endothelial cell loss per month and the endothelial cell loss per year were described at the Table 2. The mean of endothelial cell loss was 0,7% per month and 8,45% per year.
This is the first study of clinical cases to demonstrates the endothelial cell mosaic characteristics and the percentage of the endothelial cell loss after implant of drainage device even considering examinations with sample error smaller than 5% using reliability indexes specially developed to specular microscopy.
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