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Peter Walter, Babac Mazinani, Sabine Baumgarten, Amelie Pielen, ; Vitrectomy with or without encircling band for the treatment of pseudophakic retinal detachment - the prospective randomized VIPER trial. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2333.
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To determine the potential benefit of an additional encircling band in primary vitrectomy with gas for the repair of rhegmatogenous pseudophakic retinal detachment (PRD).
Patients with PRD were enrolled in a prospective randomized multicenter clinical trial and treated either by 20 G vitrectomy with gas (control group C) or by 20 G vitrectomy with gas and encircling band (experimental group E1). A smaller proportion of patients was randomized to a third exploratory arm and treated with 23 or 25 G vitrectomy with gas alone (experimental group E2). The primary endpoint was the absence of any indication for a second retina specific procedure within a follow-up of six months after the primary surgery. Secondary endpoints were visual acuity, refraction and adverse events. The study was performed within the German retina.net framework (www.retina-net.uni-koeln.de).
The VIPER trial is registered in the German Clinical Trials Register under DRKS00003158. Between August 2011 and August 2013 257 patients were enrolled in the study. 14 vitreoretinal centers participated in the trial. 100 Patients were randomized to groups C and E1, 57 patients were randomized to group E2. Last patient last visit is scheduled for February 2014. Final outcome data will be presented at the conference.
The VIPER trial investigated the potential effect of an additional encircling band in primary vitrectomy with gas for pseudophakic retinal detachment. The VIPER trial results will also indicate if transconjunctival 23 or 25 G vitrectomy with gas alone is of similar efficacy in this condition.
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