April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
FocalSeal® for Closure of Sutureless Sclerotomies of Vitrectomy: An In Vivo and Histological Study
Author Affiliations & Notes
  • Shoko Ishida
    Ophthalmology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan
  • Fumiki Okamoto
    Ophthalmology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan
  • Sujin Hoshi
    Ophthalmology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan
  • Shinichi Fukuda
    Ophthalmology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan
  • Yoshimi Sugiura
    Ophthalmology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan
  • Mikki Arai
    Arai Eye Clinic, Fukuoka, Japan
    The Schepens Eye Research Institute, Harvard Medical School, Boston, MA
  • Tatsuo Hirose
    The Schepens Eye Research Institute, Harvard Medical School, Boston, MA
  • Tetsuro Oshika
    Ophthalmology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan
  • Footnotes
    Commercial Relationships Shoko Ishida, None; Fumiki Okamoto, genzyme (F); Sujin Hoshi, None; Shinichi Fukuda, None; Yoshimi Sugiura, None; Mikki Arai, None; Tatsuo Hirose, None; Tetsuro Oshika, None
  • Footnotes
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Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2337. doi:
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      Shoko Ishida, Fumiki Okamoto, Sujin Hoshi, Shinichi Fukuda, Yoshimi Sugiura, Mikki Arai, Tatsuo Hirose, Tetsuro Oshika; FocalSeal® for Closure of Sutureless Sclerotomies of Vitrectomy: An In Vivo and Histological Study. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2337.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: FocalSeal® is an absorbable polyethylene glycol-based synthetic hydrogel sealant. This liquid is polymerized under visible xenon illumination, and forms clear, flexible, and firmly adherent hydrogel. In this study, we evaluated the ability of FocalSeal® to close sclerotomies of microincision vitrectomy.

Methods: Dutch pigmented normal rabbits were used in this in vivo study. We performed 23-gauge 3-port vitrectomy on a unilateral eye of each study animal. The sclerotomy was made by inserting a 23-gauge microvitreoretinal knife at an angle of 45° transconjunctivally. After core vitrectomy, vitreous gel around the cannula was removed with the vitrectomy cutter and then fluid-air exchange was performed. After cannulas except for irrigation were removed, 0.625% Povidone-iodine was dropped over the conjunctiva on the sclerotomy site to confirm air leakage from the sclerotomy. Then, FocalSeal® was injected subconjunctivally to cover the sclerotomies, and was polymerized with 60-second application of xenon light. Povidone-iodine was again dropped over the conjunctiva on the sclerotomy site to check whether air leakage from the sclerotomies exists. The eyes were enucleated 7 days after operation for histological examinations.

Results: After subconjunctival injection and application of xenon light, FocalSeal® polymerized rapidly. No air leakage was observed when povidone-iodine was dropped over the sclerotomy site. On histological examination, linear scar formations were observed at the sclerotomy sites and sclerotomy tunnels were tightly closed.

Conclusions: This experiment suggests that FocalSeal® allows secure closure of sutureless vitrectomy incisions.

Keywords: 688 retina • 762 vitreoretinal surgery  
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