April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Age-Related Changes of Human Corneal Epithelial Thickness by Anterior Segment Optical Coherence Tomography
Author Affiliations & Notes
  • YUJING YANG
    Eye&ENT Hospital of Fudan University, Shanghai, China
  • JianJiang Xu
    Eye&ENT Hospital of Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships YUJING YANG, None; JianJiang Xu, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2457. doi:
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      YUJING YANG, JianJiang Xu; Age-Related Changes of Human Corneal Epithelial Thickness by Anterior Segment Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2457.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To measure corneal and limbal epithelial thickness (ET) in normal subjects and to evaluate its variation with age by using anterior segment optical coherence tomography (AS-OCT).

 
Methods
 

180 normal subjects(180 healthy eyes) were enrolled and divided into four groups according to age: A(0-20 years), B(21-40 years), C(41-60 years), D(>60 years). Cornea and limbus were imaged with OCT. Corneal ET was obtained automatically by the built-in analysis software of the OCT system. Limbal ET in four quadrants was manually measured from OCT images.

 
Results
 

ETs of central 2-mm diameter cornea in groups A, B, C, D were 53.44±2.78μm, 53.36±2.71μm, 53.22±2.99μm and 52.89±3.30μm, respectively, showing no significant change with aging. In the paracentral cornea extending to 6-mm diameter, correlation analysis suggested that ET was inversely associated with age (p<0.05). ETs of the nasal and the temporal limbus were similar and decreased with aging, the averages were 58.28±8.10μm, 54.07±6.40μm, 51.21±6.07μm, 51.58±5.24μm for groups A, B, C and D, respectively; while age seemed to have no effect on ET of the superior and the inferior limbus.

 
Conclusions
 

The paracentral corneal epithelium, as well as the nasal and temporal limbal epithelium, became thinner with aging, while the central corneal ET seemed to remain constant. AS-OCT measurement of corneal and limbal epithelial thickness could aid in clinical assessment and planning treatments of the anterior cornea.

 
 
FIGURE 1. Average corneal ET(μm) categorized by age group. Black region indicates where ET is NOT significantly correlated with age, while white region indicates a negative correlation between ET and age (significance level at p<0.05, *p<0.01, **p<0.001; I, inferior; S, superior; N, nasal; T, temporal).
 
FIGURE 1. Average corneal ET(μm) categorized by age group. Black region indicates where ET is NOT significantly correlated with age, while white region indicates a negative correlation between ET and age (significance level at p<0.05, *p<0.01, **p<0.001; I, inferior; S, superior; N, nasal; T, temporal).
 
 
TABLE 1. Average Limbal ET Categorized by Age Group and its Correlation with Age
 
TABLE 1. Average Limbal ET Categorized by Age Group and its Correlation with Age
 
Keywords: 482 cornea: epithelium • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 413 aging  
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