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Lacey Haines, Kirstie Carter, Sebastian Marschall, Ahmed Gawish, Alex Wong, Paul Fieguth, Luigina Sorbara, Kostadinka K Bizheva; Comparison of Corneal Thickness Measured with Swept Source Anterior Segment Optical Coherence Tomographer, Pentacam and Ultrasound. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2464.
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To compare the measurements of total corneal thickness (TCT) using the UP-1000 Ultrasonic Pachymeter (US) and the Pentacam HR® topographer (PT) versus a research grade swept source optical coherence tomographer (SS-OCT).
A high speed, research grade SS-OCT system operating in the 1060 nm wavelength region and offering 5 µm axial resolution in corneal tissue was used to acquire high resolution, 3D images of the human cornea from eight healthy volunteers (16 eyes). Custom ray tracing and segmentation algorithms were developed to properly scale the OCT images and measure automatically total corneal thickness over the entire cornea. Full and central corneal thicknesses were also measured with a Pentacam HR® topographer. Central thickness was measured using the UP-1000 Ultrasonic Pachymeter for comparison. The corneal thickness data were analyzed using Statistica 7.
The mean age of the participants were 33±12 years and there were four females and four males. The average CCT was 532.52 ± 32.45 µm using the US and 539.56 ±30.34µm with the PT, compared to 531.77±35.19µm with the SS-OCT. There were no significant differences between mean CCT comparing each of the measurement methods (p>0.05). Using the regression analysis between US and SS-OCT measurements, R2 = 0.77 and between the PT and SS-OCT, the R2 = 0.86. Both of which were highly significant (p<0.001).
Based on this small sample size the measurements obtained with our method of analysis of the research grade SS-OCT are comparable to the other two devices. This indicates that the images obtained are of sufficient quality for valid and reliable corneal thickness measurements. Therefore, in addition to high resolution morphological imaging of the cornea, SS-OCT can provide precise morphometric analysis of the human cornea.
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