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Yun Taek Kim, Ji Won Kim; Comparison of Subfoveal Choroidal Thickness in Healthy Pregnancy and Preeclampsia. Invest. Ophthalmol. Vis. Sci. 2014;55(13):257.
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Pregnancy is a known predisposing factor for central serous chorioretinopathy (CSC). Choroidal thickness (CT) increases in patients with CSC. This study was designed to evaluate changes in CT during pregnancy.
This was an observational study. Fourteen healthy pregnant women and seven patients with pre-eclampsia were included. Twenty-one normal subjects were also recruited. CT was measured using enhanced-depth imaging optical coherence tomography (EDI-OCT).
The mean CT values of normal subjects, healthy pregnant women, and patients with preeclampsia were 264±21.03, 274.23±18.97, and 389.79±25.13 µm, respectively (normal subjects vs. healthy gravidas: P>0.05; normal subjects vs. preeclampsia: P<0.001; healthy gravidas vs. pre-eclampsia: P<0.001). CT decreased from 381.05 ± 22.96 µm to 335.17±9.97µm 1 week after delivery in patients with pre-eclampsia.
Pregnancy itself did not increase CT, whereas pre-eclampsia did appear to result in increased CT. This suggests that additional unknown factors induce hyperpermeability in pregnant women. An ophthalmic examination, including OCT, is recommended for pregnant women.
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