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Frank D Verbraak, Nazli Demirkaya, Sophie Cohen, Dasja Pajkrt, Michael David Abramoff, ; Neuro-retinal degeneration in HIV-positive children (NOVICE-study). Invest. Ophthalmol. Vis. Sci. 2014;55(13):2819.
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To detect the presence of a possible neuro-retinal degeneration in HIV-positive children
Thirty-three children (17 boys, 16 girls, mean age 13.7 y, range 8.0-18.0 y), HIV positive since birth, and 36 HIV negative children(19 boys, 17 girls, mean age 13.1 y, range 8.1 to 17,8 y) were examined with FD-OCT (Topcon, Marck II), Lanthony D15 desaturated color vision test, Mars-charts contrast sensitivity, and Rarebit-test (central visual field).
There was no difference in any individual retinal layer thickness (including macular ganglion cell layer and peripapillary retinal nerve fibre layer) between HIV positive children compared to the control group. Also all functional tests did not show a significant difference. There was also no association between age ( HIV-exposure) and retinal structure or visual function.
In contrast to previous studies in HIV positive children and in HIV positive adults, this study found no significant differences in retinal structure or visual function in HIV positive children compared to a matched control group. Analysis of HIV-disease markers like CD4 and CD8 and influence of co-morbidity awaits further analysis.
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