April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Neuro-retinal degeneration in HIV-positive children (NOVICE-study)
Author Affiliations & Notes
  • Frank D Verbraak
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, Netherlands
    Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands
  • Nazli Demirkaya
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, Netherlands
  • Sophie Cohen
    Child Care, Academic Medical Center, Amsterdam, Netherlands
  • Dasja Pajkrt
    Child Care, Academic Medical Center, Amsterdam, Netherlands
  • Michael David Abramoff
    Ophthalmology, Iowa University Hospital, Iowa, IA
  • Footnotes
    Commercial Relationships Frank Verbraak, None; Nazli Demirkaya, None; Sophie Cohen, None; Dasja Pajkrt, None; Michael Abramoff, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2819. doi:
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    • Get Citation

      Frank D Verbraak, Nazli Demirkaya, Sophie Cohen, Dasja Pajkrt, Michael David Abramoff, ; Neuro-retinal degeneration in HIV-positive children (NOVICE-study). Invest. Ophthalmol. Vis. Sci. 2014;55(13):2819.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To detect the presence of a possible neuro-retinal degeneration in HIV-positive children

Methods: Thirty-three children (17 boys, 16 girls, mean age 13.7 y, range 8.0-18.0 y), HIV positive since birth, and 36 HIV negative children(19 boys, 17 girls, mean age 13.1 y, range 8.1 to 17,8 y) were examined with FD-OCT (Topcon, Marck II), Lanthony D15 desaturated color vision test, Mars-charts contrast sensitivity, and Rarebit-test (central visual field).

Results: There was no difference in any individual retinal layer thickness (including macular ganglion cell layer and peripapillary retinal nerve fibre layer) between HIV positive children compared to the control group. Also all functional tests did not show a significant difference. There was also no association between age ( HIV-exposure) and retinal structure or visual function.

Conclusions: In contrast to previous studies in HIV positive children and in HIV positive adults, this study found no significant differences in retinal structure or visual function in HIV positive children compared to a matched control group. Analysis of HIV-disease markers like CD4 and CD8 and influence of co-morbidity awaits further analysis.

Keywords: 550 imaging/image analysis: clinical • 688 retina • 415 AIDS/HIV  
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