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Victoria Chang, Regis P Kowalski; Trends of Methicillin- Resistant Staphylococcus Aureus (MRSA) Keratitis in Western Pennsylvania: A 14- year study. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2825.
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© ARVO (1962-2015); The Authors (2016-present)
To report the incidence, current trends, and patterns of laboratory resistance to antimicrobial agents of culture- proven Methicillin (Oxacillin)- resistant S. aureus keratitis in Western Pennyslvania from 1998 to 2012
Setting: UPMC Eye Center, Pittsburgh, PA Study Population: During this 14- year period, 262 specimens of Staphylococcus aureus cultured from clinician confirmed keratitis cases in Western Pennsylvanian were included in this study. 37.8% (99 out of 262) of cases were found to be Methicillin (oxacillin)- resistant.. In vitro susceptibilities to selected antibiotics (Bacitracin, Vancomycin, Gentamycin, Ciprofloxacin, Cefazolin, Tobramycin, Sulfamethoxazole/trimethoprim, Polymyxin B) were determined by Kirby- Bauer disc diffusion method. The incidence of MRSA isolates and changes in the proportion of bacteria resistant to selected antibiotics were calculated and determined using the student t- test and cross- tabulation statistics with SPSS software.
Between 1998 and 2012, there was no statistically significant change in laboratory resistance of staphylococcus aureus to methicillin (p>0.05, 0.23% in 1998 and 0.38% in 2012). 90% or greater susceptibility: Of specimens that were resistant to oxacillin, 100% and 96.9% were susceptible to Vancomycin and Sulfacetamide, respectively. 80% or greater susceptibility: 88.4% and 88.3% of MRSA specimens were susceptible to Bacitracin and Gentamycin, respectively. Of note, there were poor susceptibilities to the fourth- generation fluroquinolones: 24.4% susceptibility to Gatifloxacin and 30.9% susceptibility to Moxifloxacin. Only 19.2% of MRSA specimens tested were susceptible to Ciprofloxacin.
Our study demonstrates a stable incidence of MRSA isolates in a 14- year period in Western Pennsylvania. There were good susceptibilities to Vancomycin, Sulfacetamide, Bacitracin, and Gentamycin. There were poor susceptibilities to the fluoroquinolones.
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