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Magdalena Baratsits, Ferdinand Georg Schlanitz, Philipp Ken Roberts, Stefan Zotter, Bernhard Baumann, Michael Pircher, Christoph K Hitzenberger, Ursula Schmidt-Erfurth; Identification and Characterization of Pseudodrusen using Polarization-Sensitive Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):284.
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To identify pseudodrusen and to describe their characteristics in eyes with age-related macular degeneration using polarization-sensitive optical coherence tomography (PS-OCT).
For this study, eyes of patients with age-related macular degeneration were scanned using a wide-field PS-OCT (Scanning area 40°x40°, volume scan 1024x250). Additionally, a standard spectral-domin OCT (SD-OCT) scan (20°x20°, 1024x97) was obtained. Two expert graders evaluated each volume scan for the presence of pseudodrusen. Furthermore, using the PS-OCT scans, the characteristics of these structures were evaluated with special regards to their correlation with the underlying retinal pigment epithelium (RPE) which is segmented automatically by the PS-OCT.
100 eyes with AMD were evaluated using both PS-OCT and SD-OCT. Pseudodrusen showed distinct structural characteristics which could have a considerable impact on the structural identity of the RPE, notably an "embedding" within the RPE-layer. In some cases, pseudodrusen seemed to be connected with drusenoid structures below the RPE. Due to the wide-field scanning area, a grading of extensive areas of pseudodrusen was possible.
Due to the ability of the PS-OCT to segment and depict the RPE, subretinal structures characteristic for pseudodrusen can be graded in a more reliable way than compared to intensity-based images alone. Structural characteristics could be observed, with special regard to their impact on the underlying RPE-layer, which might be important for a better understanding of the nature and development of pseudodrusen.
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